Evaluation of anti-viral activity of Jatropha curcas leaf extracts against potentially drug-resistant HIV isolates

نویسندگان

  • Ritwik Dahake
  • Soumen Roy
  • Deepak Patil
  • Abhay Chowdhary
  • Ranjana A Deshmukh
چکیده

Methods In vitro micro-co-culture was employed for virus isolation followed by drug susceptibility assays to determine resistance to Azidothymidine (AZT) and Lamivudine (3TC). Jatropha curcasleaves were extracted using Soxhlet apparatus. Methanolic (ME) and aqueous (AE) extracts were chosen for further study. Secondary metabolites were detected by High-Performance Thin Laye rChromatography and in vitro cytotoxicity established by MTT assay. Anti-viral activity was evaluated by p24 inhibitionin postand pre-infection interaction studies.

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عنوان ژورنال:

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2012